Browsing Doctoral Theses by Subject "Zampanolide"

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Characterisation of Zampanolide as a Microtubule-Stabilizing Agent

Field, Jessica J. (Victoria University of Wellington, 2013)

Microtubule-stabilizing agents (MSAs) are extremely important chemotherapeutic drugs since microtubules (MTs) are one of the most successful cancer drug targets. Currently there are four MSAs that are clinically used for ...
Chasing "Zampanalogs": Advancing the Synthesis of the Zampanolide Macrocycle

Geyrhofer, Sophie (Victoria University of Wellington, 2018)

(-)-Zampanolide (1), a natural product isolated from a marine sponge, is a microtubule-stabilizing agent that exhibits activity in the nanomolar range against various cancer cells, including in P-gp pump overexpressing ...