Victoria University

Synthesis of N-glycans implicated in asthma and allergy

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dc.contributor.advisor Timmer, Mattie
dc.contributor.advisor Stocker, Bridget Haslett, Gregory William 2015-03-15T22:14:00Z 2012 2011 2011
dc.description.abstract Asthma and allergies affect a large number of people, with over 300 million people worldwide suffering from asthma alone. Although, on the ‟macroscopic‟ level, it is known how allergens trigger allergic reactions, it is not known how an allergen's ‟micro‟ structure causes such a profound allergic response in sensitised individuals. A review of inter-species carbohydrate motifs revealed a striking similarity between carbohydrate moieties (N-glycans) present on antigens derived from species known to give an allergic T helper (Th) 2 response in humans (such as pollen, schistosomes, and food allergens). Preliminary studies on mixtures of allergen extracts have suggested that these carbohydrate motifs (glycoproteins) bias the immune response to an allergic (Th2) response. This project presents work conducted towards the synthesis of three fragments of a larger N-glycan found on allergens. The synthesis of these N-glycans will allow the first detailed study regarding the relationship between N-glycan structure and Th2 bias to be performed and thereby aid in our understanding of the molecular triggers of asthma. Ultimately, this could lead to the elucidation of the mechanisms of the allergic Th2 immune response. en_NZ
dc.language.iso en_NZ
dc.publisher Victoria University of Wellington en_NZ
dc.subject N-Glycans en_NZ
dc.subject Asthma en_NZ
dc.subject Allergy en_NZ
dc.title Synthesis of N-glycans implicated in asthma and allergy en_NZ
dc.type Text en_NZ
vuwschema.contributor.unit School of Chemical and Physical Sciences en_NZ
vuwschema.subject.marsden 320201 Allergy en_NZ
vuwschema.subject.marsden 320305 Medical Biochemistry: Proteins and Peptides en_NZ
vuwschema.type.vuw Awarded Research Masters Thesis en_NZ Chemistry en_NZ Victoria University of Wellington en_NZ Master's en_NZ Master of Science en_NZ
vuwschema.subject.anzsrcfor 119999 Medical and Health Sciences not elsewhere classified en_NZ

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