Victoria University

The Role of the Dopamine D₁ Receptor in the Negative Symptoms of Schizophrenia

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dc.contributor.advisor Ellenbroek, Bart Vanden Broeke, Marie 2018-03-06T02:20:20Z 2018-03-06T02:20:20Z 2016 2016
dc.description.abstract Diminished motivation is a core feature of schizophrenia that has been linked to impaired functional outcomes. A mechanism thought to contribute to diminished motivation is impaired anticipatory pleasure. Impaired anticipatory pleasure is associated with disrupted reward prediction and reduced engagement in reward-seeking behaviours. To investigate the role of the dopamine D₁ receptor in anticipatory pleasure, D₁ mutant rats and WT rats performed five experiments. Reward prediction was examined using the anticipatory locomotion experiment and successive negative contrast experiment. It was found that D₁ mutant rats have impaired anticipatory responses to expected reward. However, as the WT rats did not show the expected response to an alteration in reward expectation, it was impossible to assess the role of the D₁ receptor. Together, these findings suggest that the D₁ receptor may be involved in aspects of reward prediction. Reward-seeking behaviour was examined using the social approach experiment, scent marking experiment, and the separation induced vocalization experiment. It was found that the D₁ mutant rats have an impaired ability to engage in social and sexual reward-seeking behaviours, but have relatively normal ability to engage in maternal reward-seeking behaviours. Together, these findings indicate that the D₁ receptor is involved in certain aspects of reward-seeking behaviours. In conclusion, there is compelling evidence that a D₁ receptor dysfunction is a likely contributor to diminished motivation in schizophrenia. en_NZ
dc.language.iso en_NZ
dc.publisher Victoria University of Wellington en_NZ
dc.subject Dopamine D₁ receptor en_NZ
dc.subject Negative symptoms of schizophrenia en_NZ
dc.subject Anticipatory pleasure en_NZ
dc.subject Reward-seeking behaviour en_NZ
dc.subject Diminished motivation en_NZ
dc.title The Role of the Dopamine D₁ Receptor in the Negative Symptoms of Schizophrenia en_NZ
dc.type text en_NZ
vuwschema.contributor.unit School of Psychology en_NZ
vuwschema.type.vuw Awarded Research Masters Thesis en_NZ Cognitive and Behavioural Neuroscience en_NZ Victoria University of Wellington en_NZ Masters en_NZ Master of Science en_NZ
dc.rights.license Creative Commons GNU GPL en_NZ
dc.rights.license Allow modifications en_NZ
dc.rights.license Allow commercial use en_NZ 2018-02-20T22:00:54Z
vuwschema.subject.anzsrcfor 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) en_NZ
vuwschema.subject.anzsrctoa 1 PURE BASIC RESEARCH en_NZ

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