Victoria University

Comparison of Methamphetamine and MDMA Extended Access Self-administration: Acquisition, Maintenance, and Response Patterns

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dc.contributor.advisor Schenk, Susan Maan, Alex 2020-06-09T23:16:26Z 2020-06-09T23:16:26Z 2020 2020
dc.description.abstract Rationale. 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine are two amphetamine derivatives with contrasting pharmacological profiles. Therefore, self- administration profiles might be expected to reflect these differences. Objectives. This study compared the latency and proportion to acquire self-administration, maintenance of self-administration, and within-session response patterns. Methods. Rats were given extended access (8-hour daily sessions) to either methamphetamine, MDMA or vehicle self-administration over a period of 10 consecutive days. A criterion based on the performance of the vehicle control group was used to determine acquisition of reliable MDMA and methamphetamine self-administration. In conjunction, for MDMA self-administration the infusion dose was halved for each rat that achieved a total of 85mg/kg for the remaining sessions. Temporal patterns of responding were assessed using hourly data of the first day of self-administration, the day following acquisition, and the final day of self-administration. Results. A greater proportion of rats in the methamphetamine group acquired self- administration and self-administration was acquired with a shorter latency compared to the MDMA group. Responding maintained by methamphetamine on day one was high. By the third day a pattern developed that was maintained throughout testing. The greatest proportion of responding occurring within the first hour of each daily test session. A progressive escalation of intake was also observed within the methamphetamine group. Responding maintained by MDMA was low on the first day, but by day 5 responding had increased with most of the responding within the session occurring during the first three hours. On day 10 the greatest amount of responding occurred during the first hour. No escalation of intake as a function of test day was observed for MDMA self-administration. en_NZ
dc.language.iso en_NZ
dc.publisher Victoria University of Wellington en_NZ
dc.subject addiction en_NZ
dc.subject MDMA en_NZ
dc.subject Methamphetamine en_NZ
dc.title Comparison of Methamphetamine and MDMA Extended Access Self-administration: Acquisition, Maintenance, and Response Patterns en_NZ
dc.type Text en_NZ
vuwschema.contributor.unit School of Psychology en_NZ
vuwschema.type.vuw Awarded Research Masters Thesis en_NZ Psychology en_NZ Victoria University of Wellington en_NZ Masters en_NZ Master of Science en_NZ
dc.rights.license Author Retains Copyright en_NZ 2020-05-25T23:21:22Z
vuwschema.subject.anzsrcfor 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) en_NZ
vuwschema.subject.anzsrcseo 970117 Expanding Knowledge in Psychology and Cognitive Sciences en_NZ
vuwschema.subject.anzsrctoa 1 PURE BASIC RESEARCH en_NZ

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