Te Herenga Waka—Victoria University of Wellington
→
Library Home
→
ResearchArchive Home
→
Wellington Faculty of Science · Te Wahanga Putaiao
→
School of Biological Sciences · Te Kura Mātauranga Koiora
→
Browsing School of Biological Sciences · Te Kura Mātauranga Koiora by Title

Browsing School of Biological Sciences · Te Kura Mātauranga Koiora by Title

Now showing items 96-115 of 587

Demographics of Etmopterus lucifer (Lucifer dogfish)

Galland, Annie Rose (Victoria University of Wellington, 2015)

This study provides the first comprehensive description of the demographics of lucifer dogfish (Etmopterus lucifer) from the Chatham Rise, New Zealand during January 2012. Lucifer dogfish is a non-QMS species commonly taken ...
Demography and impacts of habitat degradation on the giant barrel sponge Xestospongia spp. in the Indo-Pacific

McGrath, Emily (Victoria University of Wellington, 2018)

Coral cover worldwide is in decline largely due to anthropogenic influence. In some areas reefs are transitioning into alternative states dominated by sponges, which remain largely understudied despite their abundance and ...
Design and Synthesis of a Highly Simplified Pateamine Analogue

Brown, Sarah (Victoria University of Wellington, 2016)

Pateamine (1) is a natural product from the marine sponge Mycale hentscheli that exhibits potent anticancer properties, and has potential as an antiviral agent, and in preventing the muscle wasting disorder cachexia. This ...
Designing accurate and effective means for marine ecosystem monitoring incorporating species distribution assessments

Jones, Timothy (Victoria University of Wellington, 2014)

Monitoring marine ecosystems is essential for the conservation and management of marine biodiversity as it is central to the development of sustainable management practices and for assessing the effectiveness of the ...
Designing Strategies to Improve the T Cell Mediated Immunotherapy of Mouse Tumours.

Ataera, Haley (Victoria University of Wellington, 2009)

The adoptive transfer of activated dendritic cells (DC) loaded with tumour antigen or tumour specific T cells improves weak anti-tumour responses, however, without treatments to relieve suppression, these therapies will ...
Detecting inbreeding depression in a severely bottlenecked, recovering species: The little spotted kiwi (Apteryx owenii)

Taylor, Helen R. (Victoria University of Wellington, 2014)

Population bottlenecks reduce genetic variation and population size. Small populations are at greater risk of inbreeding, which further erodes genetic diversity and can lead to inbreeding depression. Inbreeding depression ...
Developing a Cell Based Screen for Inhibitors of Two Component Signal Transduction in Mycobacteria

Dempsey, Sandi Grainne (Victoria University of Wellington, 2009)

The growing number of drug resistant strains of Mycobacterium tuberculosis appearing worldwide has had an enormous impact on the ability to control and treat Tuberculosis (TB). Discovering new anti-TB drugs is of paramount ...
Development and Application of Otolith-Based Methods to Infer Demographic Connections in a Marine Metapopulation

Neubauer, Philipp (Victoria University of Wellington, 2012)

Connectivity between local populations is critical if these are to function as a metapopulation and sustain locally open sink populations. Assessing whether such connections between local populations exist is thus an ...
Development and identification of candidate aptamers for growth differentiation factor 9

Robb, Orin (Victoria University of Wellington, 2018)

Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-secreted growth factors that are essential for fertility and ovarian development in many mammalian species. It is hypothesised ...
Development and validation of a novel counter-immunoelectrophoresis assay for the detection of antibodies against extractable nuclear antigens

Wallis, Reuben (Victoria University of Wellington, 2012)

The identification of autoantibodies is a primary diagnostic marker for the diagnosis of some autoimmune diseases. The sera of patients with connective tissue diseases commonly contain autoantibodies that target nuclear ...
Development of an in Vitro Assay to Assess Gap Junction Activity in Cumulus-Oocyte Complexes (COC) in the Rat

Patel, Shruti (Victoria University of Wellington, 2009)

The capacity of an oocyte to mature during ovarian follicular development is a key process in reproductive biology. Bidirectional communication between mammalian oocytes and their associated follicular somatic cells ...
Development of a System to Probe the Differential Production of elF4A from the Paralogous Genes TIF1 and TIF2 in Saccharomyces Cerevisiae

Jones, Darryl (Victoria University of Wellington, 2012)

The aim of this Master’s thesis was to evaluate the hypothesis that the Saccharomyces cerevisiae homologs for Eukaryotic Initiation Factor 4A, TIF1 and TIF2, can be individually regulated. This may be an expectation if the ...
Development of bacterial nitroreductase enzymes for noninvasive imaging in cancer gene therapy

Williams, Elsie May (Victoria University of Wellington, 2013)

There is strong interest in developing novel targeted cancer therapies. It has been known for over a century that certain viruses and bacteria can preferentially infect and lyse cancerous cells. Clinical utility has lagged ...
Diagnostic Markers for Schistosome-Mediated Liver Disease

Manivannan, Bhagyashree (Victoria University of Wellington, 2010)

Chronic schistosomiasis presents with either a moderate or a severe form, termed intestinal (INT) or hepatosplenic (HS) schistosomiasis, respectively. The Schistosoma mansoni-associated hepatomegaly is estimated in 8.5 ...
Direct and indirect interactions of native and introduced species in coastal habitats

Krejcek, Susanne Claudia (Victoria University of Wellington, 2014)

Current research has emphasized the need to identify and quantify the effects of positive and negative interactions (both direct and indirect) between species, taking into account the influence of abiotic conditions and ...
Directed Evolution and Discovery of Nitroreductase Enzymes for Targeted Cell Ablation

Little, Rory Fox (Victoria University of Wellington, 2015)

Nitroreductase enzymes are a superfamily of bacterial flavoproteins that can catalyze the reduction of aromatic nitro groups. The reduction of an aromatic nitro group, a highly electronegative functionality, causes a large ...
Discovery and Biosynthesis of Natural Products from New Zealand Soil Metagenome Libraries

Stevenson, Luke (Victoria University of Wellington, 2020)

Antibiotic discovery rates dramatically declined following the “golden age” of the 1940’s to the 1960’s. The platforms that underpinned that age of discovery rested upon laboratory cultivation of a small clade of bacteria, ...
Discovery and directed evolution of nitroreductase enzymes for activation of prodrugs and PET imaging compounds

Rich, Michelle Hedley (Victoria University of Wellington, 2017)

Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic drugs, antibiotics and environmental pollutants, have shown promise in the activation of prodrugs such as CB1954 and ...
Discovery and Optimisation of Bacterial Nitroreductases for Use in Anti-Cancer Gene Therapy

Prosser, Gareth Adrian (Victoria University of Wellington, 2011)

Nitroaromatic prodrugs are biologically inert compounds that are attractive candidates for anti-cancer therapy by virtue of their ability to be converted to potent DNA alkylating agents by nitroreductase (NTR) enzymes. In ...
Discovery, Characterisation and Engineering of Non-Ribosomal Peptide Synthetases and Phosphopantetheinyl Transferase Enzymes

Robins, Katherine (Victoria University of Wellington, 2016)

Non-ribosomal peptide synthetases (NRPSs) are multi-modular biosynthetic enzymes that are responsible for the production of many bioactive secondary metabolites produced by microorganisms. They are activated by phosphopantetheinyl ...